## Abstract Proliferating cells, particularly the tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed M2βPK. It's a direct target of several oncoproteins; the determination of fecal tumor pyruvate kinase type M2 (M2βPK) might be another promising tool for colorectal cancer (CRC) scr
Current Status of Tumor M2 Pyruvate Kinase (Tumor M2-PK) as a Biomarker of Gastrointestinal Malignancy
β Scribed by Harsha R. Hathurusinghe; Kolitha S. Goonetilleke; Ajith K. Siriwardena
- Book ID
- 111772101
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 208 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1068-9265
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## Abstract Proliferating cells express the pyruvate kinase isoenzyme type M2 (M2βPK). This enzyme exists as an active tetramer and an inactive dimer. The dimeric form is predominantly found in tumor cells and is therefore termed Tumor M2βPK (TuM2βPK). TuM2βPK molecules are released into the periph
Background: Fecal inflammatory markers have been shown to be useful as noninvasive screening tools to differentiate patients with functional from organic bowel pathology. Of these markers calprotectin has been the most intensively studied. More recently, the dimeric isoform of M2-pyruvate kinase (tu