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Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin

โœ Scribed by Dale E. TRONRUD; Arthur F. MONZINGO; Brian W. MATTHEWS


Book ID
115124530
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
783 KB
Volume
157
Category
Article
ISSN
1432-1327

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Solid phase synthesis of phosphinopeptoi
โœ Peter H. Dorff; Gordon Chiu; Steven W. Goldstein; Bradley P. Morgan ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 192 KB

A procedure for preparing novel phosphinopeptolds, 1, on a solid support is described. The key step in the synthesis includes a conjugate addition of the trivalent form of a protected aminomethylphosphinic acid (5) to a resin-bound acrylate.