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Amidrazone Analogs of D-Ribofuranose as Transition-State Inhibitors of Nucleoside Hydrolase

✍ Scribed by Boutellier, Markus; Horenstein, Benjamin A.; Semenyaka, Alexi; Schramm, Vern L.; Ganem, Bruce

Book ID: 127131817
Publisher: American Chemical Society
Year: 1994
Tongue: English
Weight: 776 KB
Volume: 33
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi00179a028

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Iminoribitol Transition State Analogue I

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8-Aza-immucillins as Transition-State An

8-Aza-immucillins as Transition-State Analogue Inhibitors of Purine Nucleoside Phosphorylase and Nucleoside Hydrolases

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Synthesis of Transition State Analogue I

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✍ Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 314 KB

AbstractÐSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxy¯uoro-and 2-deoxy-analogues and others having modi®ed bases.