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Phosphonamidates as transition-state analog inhibitors of thermolysin

โœ Scribed by Bartlett, Paul A.; Marlowe, Charles K.


Book ID
125995696
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
784 KB
Volume
22
Category
Article
ISSN
0006-2960

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Solid phase synthesis of phosphinopeptoi
โœ Peter H. Dorff; Gordon Chiu; Steven W. Goldstein; Bradley P. Morgan ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 192 KB

A procedure for preparing novel phosphinopeptolds, 1, on a solid support is described. The key step in the synthesis includes a conjugate addition of the trivalent form of a protected aminomethylphosphinic acid (5) to a resin-bound acrylate.