Solid phase synthesis of phosphinopeptoids as transition state analog inhibitors

✍ Scribed by Peter H. Dorff; Gordon Chiu; Steven W. Goldstein; Bradley P. Morgan

• Book ID: 104259151
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 192 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00496-1

✦ Synopsis

A procedure for preparing novel phosphinopeptolds, 1, on a solid support is described. The key step in the synthesis includes a conjugate addition of the trivalent form of a protected aminomethylphosphinic acid (5) to a resin-bound acrylate.