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Iminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases †

✍ Scribed by Miles, Robert W.; Tyler, Peter C.; Evans, Gary B.; Furneaux, Richard H.; Parkin, David W.; Schramm, Vern L.

Book ID: 127082839
Publisher: American Chemical Society
Year: 1999
Tongue: English
Weight: 257 KB
Volume: 38
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi990829u

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📜 SIMILAR VOLUMES

Transition state analogue inhibitors of

Transition state analogue inhibitors of protozoan nucleoside hydrolases

✍ Richard H. Furneaux; Vern L. Schramm; Peter C. Tyler 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 199 KB

8-Aza-immucillins as Transition-State An

8-Aza-immucillins as Transition-State Analogue Inhibitors of Purine Nucleoside Phosphorylase and Nucleoside Hydrolases

✍ Evans, Gary B.; Furneaux, Richard H.; Gainsford, Graeme J.; Hanson, John C.; Kic 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 109 KB

Synthesis of Transition State Analogue I

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

✍ Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 314 KB

AbstractÐSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxy¯uoro-and 2-deoxy-analogues and others having modi®ed bases.

ChemInform Abstract: Synthesis of Transi

ChemInform Abstract: Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases.

✍ Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Isozyme-Specific Transition State Inhibi

Isozyme-Specific Transition State Inhibitors for the Trypanosomal Nucleoside Hydrolases †

✍ Parkin, David. W.; Limberg, Gerrit; Tyler, Peter C.; Furneaux, Richard H.; Chen, 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 243 KB

Synthesis of Bicyclic N-Arylmethyl-Subst

Synthesis of Bicyclic N-Arylmethyl-Substituted Iminoribitol Derivatives as Selective Nucleoside Hydrolase Inhibitors

✍ Maya Berg; Gunther Bal; Annelies Goeminne; Pieter Van der Veken; Wim Versées; Ja 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 510 KB

## Abstract **A series of bicyclic** **__N__****‐arylmethyl‐substituted iminoribitols** were synthesised and evaluated in vitro against __T. vivax__ nucleoside hydrolase. The importance of the N–Asp40 interaction was confirmed and depends on an optimal p__K__~a~ value, which can be influenced by su