Crystallization-Induced Diastereoselection: Asymmetric Synthesis of Substance P Inhibitors
โ Scribed by Philip J. Pye; Kai Rossen; Steven A. Weissman; Ashok Maliakal; Robert A. Reamer; Richard Ball; Nancy N. Tsou; R. P. Volante; Paul J. Reider
- Book ID
- 101375336
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 106 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0947-6539
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๐ SIMILAR VOLUMES
A highly convergent, asymmetric synthesis of L-768,673, an Iks Class III antiarrythmic drug candidate, is described. Synthesis of the racemic 1-trifluoroethyl-3-amino-5-phenyl benzodiazepinone [(~-amine] was achieved by Ru-catalyzed hydrogenation of the corresponding oxime that was derived from comm
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