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Remote diastereoselection in the asymmetric synthesis of pravastatin

โœ Scribed by Daniewski, A. R.; Wovkulich, P. M.; Uskokovic, M. R.


Book ID
121855159
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
1016 KB
Volume
57
Category
Article
ISSN
0022-3263

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1,5-Remote diastereoselection on the acyclic systems is achieved by diastereoselective Cr(C0j3 complexation, chirality transfer in acyclic system and following stereoselective alkylation at the benzylic position. One of the most exciting challenges in the synthetic methodology is control of stereoch