Crystal Structure of an Elastase-Specific Inhibitor Elafin Complexed with Porcine Pancreatic Elastase Determined at 1.9 Å Resolution †
✍ Scribed by Tsunemi, Masahiko; Matsuura, Yoshiki; Sakakibara, Shumpei; Katsube, Yukiteru
- Book ID
- 126225870
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 582 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-2960
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Human leukocyte elastase (HLE) is a serine protease that contributes to tissue destruction in various disease states-for example, in emphysema. FR901277 is a natural product isolated from the culture filtrate of Streptomyces resistomicificus and is a potent inhibitor of both HLE and porcine pancreat
## Abstract A high‐resolution structure of a ligand‐bound, soluble form of human monoglyceride lipase (MGL) is presented. The structure highlights a novel conformation of the regulatory lid‐domain present in the lipase family as well as the binding mode of a pharmaceutically relevant reversible inh
An acidic phospholipase A 2 (PLA 2 ) isolated from Bothrops jararacussu snake venom was crystallized with two inhibitors: a-tocopherol (vitamin E) and p-bromophenacyl bromide (BPB). The crystals diffracted at 1.45-and 1.85-A ˚resolution, respectively, for the complexes with a-tocopherol and p-bromop