Cryosurgical ablation of soft tissue sarcomas : A phase I trial of feasibility and safety

✍ Scribed by Lawrence R. Menendez; Matthew S. Tan; Milton T. Kiyabu; Sant P. Chawla

• Book ID: 101229996
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 294 KB
• Volume: 86
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19990701)86:1<50::aid-cncr9>3.0.co;2-a

✦ Synopsis

BACKGROUND.

Cryosurgery is a therapeutic method of treating neoplastic tissue by freezing in situ to achieve devitalization. Cell death results from exposure to severe cold (below Ϫ40°C for at least 1 minute) as well as from the process of freezing and thawing, which disrupts cellular integrity. Modern cryosurgical technique involves insertion of hollow probes into the tumor, through which circulating liquid nitrogen and gaseous nitrogen can achieve tissue and tumor freezing and thawing for tumor control. Cryoablation is now a recognized approach to the treatment of various malignant tumors, and it is generally well tolerated. This method has been used only sporadically to date in the treatment of patients with soft tissue sarcomas.