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CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

✍ Scribed by Smalley, K S M; Xiao, M; Villanueva, J; Nguyen, T K; Flaherty, K T; Letrero, R; Van Belle, P; Elder, D E; Wang, Y; Nathanson, K L

Book ID
109970693
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
392 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a