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CpG island methylation in gastroenterologic neoplasia: A maturing field

✍ Scribed by Asif Rashid; Jean Pierre J. Issa

Book ID
119758097
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
211 KB
Volume
127
Category
Article
ISSN
0016-5085

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πŸ“œ SIMILAR VOLUMES

Methylation of the oestrogen receptor Cp
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
✍ Issa, Jean-Pierre J.; Ottaviano, Yvonne L.; Celano, Paul; Hamilton, Stanley R.; πŸ“‚ Article πŸ“… 1994 πŸ› Nature Publishing Group 🌐 English βš– 571 KB

We report that CpG island methylation, an epigenetic modification of DNA known to correlate closely with silencing of gene transcription, appears in the oestrogen receptor (ER) gene in a subpopulation of cells which increases as a direct function of age in human colonic mucosa. This same methylation