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Rare CpG Island Methylator Phenotype in Ulcerative Colitis–Associated Neoplasias

✍ Scribed by Kazuo Konishi; Lanlan Shen; Suna Wang; Stephen J. Meltzer; Noam Harpaz; Jean–Pierre J. Issa

Book ID
119759671
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
259 KB
Volume
132
Category
Article
ISSN
0016-5085

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## Abstract The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and __BRAF__ mutation. Genome‐wide hypomethylation may also play an important role in genomic instability. How