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The Relationship between Hypomethylation and CpG Island Methylation in Colorectal Neoplasia

✍ Scribed by Carolyn Bariol; Catherine Suter; Kay Cheong; Su-Lyn Ku; Alan Meagher; Nicholas Hawkins; Robyn Ward

Book ID
117021950
Publisher
American Society for Investigative Pathology
Year
2003
Tongue
English
Weight
302 KB
Volume
162
Category
Article
ISSN
0002-9440

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## Abstract The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and __BRAF__ mutation. Genome‐wide hypomethylation may also play an important role in genomic instability. How