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Tissue-specific methylation of a CpG island in transgenic mice

✍ Scribed by Gundersen, Glenn; Kolsto, Anne-Brit; Larsen, Frank; Prydz, Hans

Book ID
121947649
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
947 KB
Volume
113
Category
Article
ISSN
0378-1119

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## Abstract It is demonstrated that a heterologous (chicken) CpG island containing five Sp1 canonical recognition sequences becomes highly methylated in the genome of transgenic mice bearing one or several copies of the transgene. Similar levels of methylation of the chicken CpG island were observe