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Differential methylation of a CpG-island concatemer in hemi- and homozygous transgenic mice

✍ Scribed by Glenn Gundersen; Anne-Brit Kolstø; Hans Prydz

Book ID
115925675
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
484 KB
Volume
295
Category
Article
ISSN
0014-5793

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## Abstract It is demonstrated that a heterologous (chicken) CpG island containing five Sp1 canonical recognition sequences becomes highly methylated in the genome of transgenic mice bearing one or several copies of the transgene. Similar levels of methylation of the chicken CpG island were observe