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CpG Island methylation and the pathogenesis of hyperplastic polyposis

✍ Scribed by Chan, Annie O.; Issa, Jean-Pierre J.; Morris, Jeffrey S.; Hamiltton, Stanley R.; Rashid, Asif

Book ID
124112572
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
189 KB
Volume
120
Category
Article
ISSN
0016-5085

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## Abstract Genetic alterations occur during the adenoma‐carcinoma sequence of colon cancer formation and drive the initiation and progression of colon cancer formation. The aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer. The