✦ LIBER ✦

Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma

✍ Scribed by Jae Yong Cho; Joo Hang Kim; Yi Hyeong Lee; Kyung Young Chung; Sung Kyu Kim; Soo Jung Gong; Nae Choon You; Hyun Cheol Chung; Jae Kyung Roh; Byung Soo Kim

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 107 KB
Volume: 79
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19970201)79:3<462::aid-cncr6>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

RESULTS.

Fourteen mutations (24%) of ras genes were found, all at codon 12 of the K-ras gene. GGT to GAT transition was the predominant mutational pattern.

📜 SIMILAR VOLUMES

Transforming growth factor-β1 level corr

Transforming growth factor-β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

✍ Yukihiro Hasegawa; Shingo Takanashi; Yutaka Kanehira; Takao Tsushima; Tadashi Im 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 1 views

p53 Mutation and allelic loss of chromos

p53 Mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with nonsmall cell lung carcinoma

✍ Hiromasa Kohno; Kenzo Hiroshima; Tetsuya Toyozaki; Takehiko Fujisawa; Hidemi Ohw 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 1 views

## Background: An accumulation of mutations can result in carcinogenesis. comparing genetic alterations in preneoplastic lesions with those seen in cancer in the same patient may be helpful in the early diagnosis of lung carcinoma or preneoplastic lesions. ## Methods: To identify genetic alterati

Phase I trial of docetaxel and vinorelbi

Phase I trial of docetaxel and vinorelbine in patients with advanced nonsmall cell lung carcinoma

✍ Vincent A. Miller; Kenneth K. Ng; Lee M. Krug; Wendy Perez; Barbara Pizzo; Rober 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 76 KB 👁 2 views

## Background: With preclinical evidence of synergy, this dose-finding trial examining the combination of docetaxel and vinorelbine given with prophylactic filgrastim for the treatment of patients with nonsmall cell lung carcinoma was undertaken. ## Methods: Twenty-seven patients with advanced no

Cigarette smoking is strongly associated

Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung

✍ Steven A. Ahrendt; P. Anthony Decker; Enas A. Alawi; Yong-ran Zhu; Montserrat Sa 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 2 views

K-ras mutation and loss of heterozygosit

K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma

✍ N. Peter Zauber; Marlene Sabbath-Solitare; Stephen P. Marotta; D. Timothy Bishop 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 2 views

## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit

A phase II study of gemcitabine plus ora

A phase II study of gemcitabine plus oral etoposide in the treatment of patients with advanced nonsmall cell lung carcinoma

✍ Tony S. K. Mok; Benny Zee; Anthony T. C. Chan; Winnie Yeo; Wei Tse Yang; Anthony 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 2 views