Copper-promoted/catalyzed CN and CO bond cross-coupling with vinylboronic acid and its utilities
✍ Scribed by Patrick Y.S Lam; Guillaume Vincent; Damien Bonne; Charles G Clark
- Book ID
- 104253741
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 361 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The mildest method of N-vinylation has been discovered. The synthetic utilities of the N-and O-vinylated products include protecting group, cyclopropanation and Grubbs' ring closure metathesis reactions.
📜 SIMILAR VOLUMES
General catalytic Cu(OAc) 2 /TEMPO in air or Cu(OAc) 2 /O 2 systems for the C N and C O cross-coupling reactions with arylboronic acid have been discovered. N-and O-vinylation have also been demonstrated.
Acyclic and cyclic esters, as well as anhydride (boroxine) of phenylboronic acids are efficient phenylating agents in copper promoted C N and C O bond cross-coupling reactions. The first successful C N cross-coupling of a heterocyclic boronate with heteroarenes, such as indazole, has been demonstrat