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Coordination of oxidized protein hydrolase and the proteasome in the clearance of cytotoxic denatured proteins

✍ Scribed by Kei Shimizu; Yukari Kiuchi; Ken Ando; Makio Hayakawa; Kiyomi Kikugawa


Book ID
116289152
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
720 KB
Volume
324
Category
Article
ISSN
0006-291X

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## Abstract The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidi