The nuclear proteasome and the degradation of oxidatively damaged proteins
β Scribed by P. Voss; T. Grune
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 113 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0939-4451
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidi
## Abstract Others and we previously showed that the vitamin D receptor (VDR) is subject to degradation by the 26S proteasome and that treatment with 1,25βdihydroxyvitamin D~3~ (1,25D~3~) inhibited this degradation. In the present study, we found that in osteoblasts, but not in intestinal epithelia
## Abstract Nuclear receptors (NRs) represent a class of transcription factors that associate with both positive and negative chromatin modifying complexes to activate or repress gene transcription. The 26S proteasome plays a major role in NRβregulated gene transcription by tightly regulating the l