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Conversion From a Calcineurin Inhibitor-Based Immunosuppressive Regimen to Everolimus in Renal Transplant Recipients: Effect on Renal Function and Proteinuria

โœ Scribed by J. Morales; A. Fierro; D. Benavente; C. Zehnder; M. Ferrario; L. Contreras; C. Herzog; E. Buckel

Book ID
116933089
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
61 KB
Volume
39
Category
Article
ISSN
0041-1345

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Improvement of renal function after the
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Chronic renal dysfunction is a frequent and severe complication in solid-organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and siro

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A randomized controlled trial of late conversion from calcineurin inhibitor (CNI)-based to sirolimus-based immunosuppression in liver transplant recipients with impaired renal function
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Renal impairment is common in patients after liver transplantation and is attributable in large part to the use of calcineurin inhibitor (CNI)-based immunosuppression. We sought to determine whether conversion to sirolimus-based immunosuppression was associated with improved renal function. In a sin