Convergent Approaches for the Synthesis of the Antitumoral Peptide, Kahalalide F. Study of Orthogonal Protecting Groups
✍ Scribed by Gracia, Carolina; Isidro-Llobet, Albert; Cruz, Luis J.; Acosta, Gerardo A.; Álvarez, Mercedes; Cuevas, Carmen; Giralt, Ernest; Albericio, Fernando
- Book ID
- 120707641
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 432 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
The first synthesis of N-Boc-protected tropanes by a [4+3] cycloaddition reaction is described. The Boc group has been cleanly removed demonstrating that this group would be very useful for the synthesis of 'tropane-like' scaffolds for combinatorial chemistry.
Triethylsilane was used as a scavenging agent in peptide synthesis for the removal of protecting groups with TFA. The efficiency of scavenging ability was compared with anisole and ethanedithiol in a kinetic experiment. It was also found that triethylsilane/TFA reduces the indole ring of tryptophan
## Abstract The value of several reagents capable of removing quantitatively the α‐amino protecting group of NPS‐aminoacyl‐ or peptidyl‐derivatives is assessed, by comparison with the reagents currently used, __i.e.__ hydrogen chloride, RS^–^‐nucleophiles or alkyl thioamides, especially with regard