Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking of protecting groups in peptide synthesis

✍ Scribed by Daniel A. Pearson; Mary Blanchette; Mary Lou Baker; Cathy A. Guindon

• Book ID: 104229265
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 225 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)99113-5

✦ Synopsis

Triethylsilane was used as a scavenging agent in peptide synthesis for the removal of protecting groups with TFA.

The efficiency of scavenging ability was compared with anisole and ethanedithiol in a kinetic experiment. It was also found that triethylsilane/TFA reduces the indole ring of tryptophan.