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Convenient synthesis of [2-14C]-methylglyoxal bis(guanylhydrazone), [14C]-mitoguazone

✍ Scribed by Alain Burgos; George J. Ellames

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
173 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[2‐^14^C]‐Methylglyoxal bis(guanylhydrazone) dihydrochloride, [^14^C]‐mitoguazone, 3, has been prepared in three steps from potassium [1‐^14^C]‐acetate in an overall radiochemical yield of 16%. The key steps in this procedure are the formation of the sodium salt of [acetone‐2‐^14^C]‐methylsulfinylacetone, 5, and Pummerer rearrangement to the [^14^C] labelled hemithioacetal, 6, which is trapped with two equivalents of aminoguanidine to afford the desired [^14^C] mitoguazone, 3.

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