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Synthesis of 14C-labelled methylglyoxal and S-D-lactoylglutathione

✍ Scribed by James D. Clelland; Paul J. Thornalley

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
336 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[2‐^14^C]Methylglyoxal and S‐D‐[2‐^14^C]lactoylglutathione were synthesised from [2‐^14^C]acetone. Acetone was oxidised to methylglyoxal by selenium dioxide and was purified by distillation (yield: 23% based on acetone). Methylglyoxal was converted to S‐D‐lactoylglutathione by reaction with reduced glutathione catalysed by glyoxalase I (EC 4.4.1.5). S‐D‐Lactoylglutathione was purified by anion exchange chromatography on Dowex 1 (yield: 82%, based on methylglyoxal).

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