## Secvndahy am&m am cleanly and kieadiey convmed xo .the cotmtipandcng N-v~&~natnin~ in tigh ykLdn undti pha?le-titi1(eri concGaXati blr mQLzMn oh nodiwn nithitc and N-h&o-
Contamination of Amines with N-Nitrosamines
โ Scribed by Dr. Bertold Spiegelhalder; Dr. Gerhard Eisenbrand; Prof. Dr. Rudolf Preussmann
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 214 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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A facile method for denitrosation of cyclic N-nitrosamines employing BF3-Furan, BF3+l!hiophene, or BF3-THF, in the presence 07 NaHCO3 is described. Carbonyl groups are not affected in this method.
2-(N,N-Dimethylaminomethyl)pyrrole reacts instantaneously with nitrous acid at 25" to produce diemthylnitrosamine, maleimidemonooxine, formaldehyde and other products. The data implicate new mechanisms of tertiary amine nitrosation. N-Alkyl tertiary amines react very slowly at 25" with nitrous acid
Dimethylnitrosamine, nitrosomorpholine, nitrosopyrrolidine, nitrosopiperidine, nitrosoazetidine, hexamethylenenitrosamine, nitrosornethylcyclohexylamine, nitrosomethylaniline and dinitrosopiperazine have been prepared labeled with tritium by nifrosation of the corresponding amines which had been lab