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Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

✍ Scribed by Robyn Catlett-Falcone; Terry H Landowski; Marc M Oshiro; James Turkson; Alexander Levitzki; Rocco Savino; Gennaro Ciliberto; Lynn Moscinski; Jose Luis Fernández-Luna; Gabriel Nuñez; William S Dalton; Richard Jove

Book ID
117722439
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
423 KB
Volume
10
Category
Article
ISSN
1074-7613

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Constitutive Activation of Stat3 Signali
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
✍ Robyn Catlett-Falcone; Terry H Landowski; Marc M Oshiro; James Turkson; Alexande 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 423 KB

Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human my