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Constitutive activation of JAK–STAT3 signaling by BRCA1 in human prostate cancer cells

✍ Scribed by Bin Gao; Xuening Shen; George Kunos; Qinghui Meng; Itzhak D. Goldberg; Eliot M. Rosen; Saijun Fan


Book ID
117102653
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
524 KB
Volume
488
Category
Article
ISSN
0014-5793

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Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human my