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Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells

โœ Scribed by Sora Park; Hyo-Jung Lee; Soo-Jin Jeong; Hyo Sook Song; Minseok Kim; Hyo-Jeong Lee; Eun-Ok Lee; Dong-Hyun Kim; Kyoo Seok Ahn; Sung-Hoon Kim


Book ID
116463732
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
631 KB
Volume
49
Category
Article
ISSN
0278-6915

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Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human my