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Constitutive activation of stat signaling in myeloid leukemia cells is associated with resistance to apoptosis

โœ Scribed by M. Huang; R. Catlett-Falcone; L. Burdelya; T. Landowski; M. Oshiro; L. Moscinski; T. Loughran; H. Saba; D. Sullivan; H. Yu; W. Dalton; R. Jove


Book ID
114216384
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
15 KB
Volume
28
Category
Article
ISSN
0301-472X

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Constitutive Activation of Stat3 Signali
โœ Robyn Catlett-Falcone; Terry H Landowski; Marc M Oshiro; James Turkson; Alexande ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 423 KB

Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human my