Four relative-pair methods for detecting genetic linkage were applied to familial Alzheimer's disease data. Results obtained using an extended Haseman-Elston test and a weighted rank pairwise correlation test, which both use information from all relative pairs, were consistent with previously publis
Consanguinity and Relative-Pair Methods for Linkage Analysis
โ Scribed by Daniel E. Weeks; Janet S. Sinsheimer
- Book ID
- 117852313
- Publisher
- American Society of Human Genetics
- Year
- 1998
- Tongue
- English
- Weight
- 68 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/301742
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Relative-pair methods for detection of linkage between a quantitative trait and a marker locus have been proposed by a number of authors [e.g., Haseman and Elston, Behav Genet 3-19,1972; Amos and Elston, Genet Epidemiot 349-360,19891. However, development of tests of significance that combine inform
When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coeff