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Conjugates of proteins with polyethylene glycol (review)

✍ Scribed by I. N. Topchieva

Book ID
112487575
Publisher
Springer
Year
1989
Tongue
English
Weight
508 KB
Volume
23
Category
Article
ISSN
0091-150X

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✍ D.L. Ladd; R.A. Snow πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 272 KB

We have developed a new class of reagents (2) for the covalent attachment of polyethylene glycol to proteins. These reagents (2) are the monomethoxypolyethylene glycol esters of 4-fluoro-3-nitrobenzoic acid. The reaction of 2 with lysine \(\epsilon\)-amino groups produces a chromophore which can be