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Polyethylene glycol-conjugated pharmaceutical proteins

โœ Scribed by Pascal Bailon; Wolfgang Berthold

Book ID
114402025
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
96 KB
Volume
1
Category
Article
ISSN
1461-5347

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โœ D.L. Ladd; R.A. Snow ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 272 KB

We have developed a new class of reagents (2) for the covalent attachment of polyethylene glycol to proteins. These reagents (2) are the monomethoxypolyethylene glycol esters of 4-fluoro-3-nitrobenzoic acid. The reaction of 2 with lysine \(\epsilon\)-amino groups produces a chromophore which can be