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Conformational studies of the copolymer poly(L-lysine, L-tyrosine) 1:1 in aqueous solution

✍ Scribed by Arlette Garnier; Lucia Tosi

Publisher
Wiley (John Wiley & Sons)
Year
1978
Tongue
English
Weight
604 KB
Volume
17
Category
Article
ISSN
0006-3525

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✦ Synopsis

The absorption and circular dichroism spectra of the 1:l copolymer (L-LYS, L-Tyr), have been investigated in aqueous solutions at pH ranging from 3 to 13. The spectral patterns indicate that the fully charged polyampholyte assumes a nonperiodic conformation on the acid and basic sides of the isoelectric point. At pH ranging from 9.2 to 11.6, the polymer is largely ordered and takes mostly an antiparallel @-structure as is shown by the infrared spectra in D20 solutions. Moreover, the rotational strength of the La transition of tyrosyl is independent of the polymer conformation, whereas that of the L b transition is strongly sensitive to it.

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