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Kinetic studies of the helix–coil transition in aqueous solutions of poly(L-lysine)

✍ Scribed by S. Inoue; T. Sano; Y. Yakabe; H. Ushio; T. Yasunaga

Publisher
Wiley (John Wiley & Sons)
Year
1979
Tongue
English
Weight
544 KB
Volume
18
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The rate of conformational change of aqueous poly(α‐L‐lysine) solutions was measured using the electric field pulse relaxation method with conductivity detection. The relaxation time as a function of pH exhibits two maxima. One is assigned to a proton transfer reaction and the other to the helix–coil conformational transition. The helix nucleation parameter and the maximum relaxation time yield the rate constant of helix growth process (k~F~) according to Schwarz's kinetic theory as k~F~ = 2 × 10^7^ sec^−1^, which is comparable to that of the poly(glutamic acid) solution. The thermodynamic parameters of the helix growth process are compared with those of poly(glutamic acid).

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