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Solution properties of synthetic polypeptides. XV. Helix–coil transition in poly (ε-carbobenzyloxy L-lysine)

✍ Scribed by Mikio Matsuoka; Takashi Norisuye; Akio Teramoto; Hiroshi Fujita

Publisher
Wiley (John Wiley & Sons)
Year
1973
Tongue
English
Weight
790 KB
Volume
12
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Helix–coil transitions of poly(ε‐carbobenzyloxy L‐lysine) (PCBL) in m‐cresol and in mixtures of dichloroacetic acid (DCA) and ethylene dichloride (EDC) were investigated by optical rotation measurements, with special interest in the molecular‐weight dependence of helical content. The data obtained were analyzed according to an approximate expression for the helical content of Okita et al. The values obtained for the cooperativity parameter σ and transition enthalpy Δ__H__ε (at the transition temperature) were: √σ = (0.25 ± 0.06) × 10^−2^ and Δ__H__~c~ = 930 ± 130 cal/mole in m‐cresol, and √σ = (0.49 ± 0.10) × 10^−2^, and Δ__H__~c~ = 350 ± 150 kcal/mole in a DCA–EDC mixture (33 vol % DCA). The Δ__H__~c~ value in the DCA–EDC mixture is much smaller than that derived by Giacometti et al. from heat of solution measurements. The transition in m‐cresol was extremely sharp. This was attributed to the unusually small value of √σ and the moderately large value of Δ__H__~c~ obtained.

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