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Solution properties of synthetic polypeptides. V. Helix–coil transition in poly(β-benzyl L-aspartate)

✍ Scribed by Yoshihisa Hayashi; Akio Teramoto; Kazuo Kawahara; Hiroshi Fujita

Publisher
Wiley (John Wiley & Sons)
Year
1969
Tongue
English
Weight
896 KB
Volume
8
Category
Article
ISSN
0006-3525

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✦ Synopsis

Simple approximate expressions have been derived from the theory of Zimm and Bragg for use in the analysis of experimental data on the helix-coil transition in polypeptide. On the basis of the resulting expressions practical procedures are proposed t o determine two basic parameters characterizing a thermally induced transition, i.e., helix initiation parameter u and enthalpy change for helix formation, AH. They have been applied to the data for poly(8-benzyl L-aspartate) (PBLA) with the result: u = 1.6 X 10-4 and A H = -450 cal/niole for PBLA in m-cresol; u = 0.6 X and A H = 260 cal/mole for PBLA in chloroform containing 5.7 vol-% of dichloroacetic acid. This result gives evidence that u may change not only from one polypeptide to another but also for a given polypeptide in different solvents. The change in limiting viscosity number [q] accompanying the transition was measured in the same solvents. The curve of [q] versus helical content had a relatively monotonic shape for the chloroformdichloroacetic acid solutions as compared with that for the m-cresol solutions, indicating that [q] depended largely on U. Provided that [q] is a direct measure of the mean-square radius of gyration, (AS*), the results are consistent with the theoretical predictions of Nagai and of Miller and Flory for (S2).

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