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Conformational studies on polypeptides. The effect of sodium perchlorate on the conformation of poly-L-lysine and of random copolymers of L-lysine and L-phenylalanine in aqueous solution

✍ Scribed by E. Peggion; A. Cosani; M. Terbojevich; G. Borin

Publisher
Wiley (John Wiley & Sons)
Year
1972
Tongue
English
Weight
595 KB
Volume
11
Category
Article
ISSN
0006-3525

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✦ Synopsis

351 00 Padova, Ilaly synopsis Circular Dichroism measurements have been carried out on poly-L-lysine (PLL) and on random copolymers of lysine and phenylalanine a t various pH values and in the presence of different amounts of NaClOr. The results indicate that either the homopolymer or the copolymers a t pH conditions a t which the side-chain amino groups are fully protonated, assume the right-handed a-helical conformation in the presence of NaC1O4. The results are interpreted in terms of specific binding of C10,ions on charged side-chain amino groups.

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