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Conformational Changes of G Protein‐Coupled Receptors During Their Activation by Agonist Binding

✍ Scribed by Bissantz, Caterina


Book ID
121326324
Publisher
Informa plc
Year
2003
Tongue
English
Weight
524 KB
Volume
23
Category
Article
ISSN
1079-9893

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Substitutions of Asn111 of the AT 1 angiotensin receptor and mutations of the corresponding amino acids in other G-protein-coupled receptors (GPCRs) cause constitutive receptor activation. Ligand binding and signalling of constitutively active mutant GPCRs are discussed and similarities and differen