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Agonist and Inverse agonist Induced Conformation Changes in G-protein Coupled Receptors

✍ Scribed by Vaidehi, Nagarajan


Book ID
123494462
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
37 KB
Volume
96
Category
Article
ISSN
0006-3495

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## Abstract It has been recently established that G‐protein‐coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so‐called inverse agonists. For a number of GPCRs, such inverse agonists have been developed a