Confirmation of the linkage HL-A/PGM3
✍ Scribed by W. R. Mayr; S. Bissbort; J. Kömpf
- Book ID
- 104917834
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 96 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0340-6717
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📜 SIMILAR VOLUMES
Linkage analysis of 7 families with 30 children confirmed previous findings of the linkage between HL-A and GLO. Out of 28 families with 90 children the highest lod score value obtained was + 8.887 (recombination fraction = 0.1).
This study confirms close linkage for the GLO--Bf--HLA-B,C,A complex, and proves linkage between the MHC loci and PGM3. For GLO--PGM3 and Bf--PGM3, respectively, loose linkage seems to be likely, and close linkage can be excluded. Our mapping data on chromosome 6 favor the hypothesis that the PGM3 l
Segregation analysis of informative families for chromosome 6 markers confirmed the map order GLO--Bf--HLA-(B, C)--HLA-A, and, surprisingly, implies that PGM3 is more probably located on the HLA-A than on the HLA-B side of the linkage group. Therefore the map position of PGM3 should be reconsidered,