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Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM3

✍ Scribed by F. Schunter; P. Wernet; J. Kömpf; S. Bissbort; F. Göhler

Publisher
Springer
Year
1978
Tongue
English
Weight
525 KB
Volume
44
Category
Article
ISSN
0340-6717

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✦ Synopsis

Segregation analysis of informative families for chromosome 6 markers confirmed the map order GLO--Bf--HLA-(B, C)--HLA-A, and, surprisingly, implies that PGM3 is more probably located on the HLA-A than on the HLA-B side of the linkage group. Therefore the map position of PGM3 should be reconsidered, i.e., more informative families should be tested for all the relevant marker loci available.

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Mapping of the linkage group GLO-Bf-HLA-
Mapping of the linkage group GLO-Bf-HLA-B,C,A-PGM3
✍ J. Kömpf; S. Bissbort; F. Göhler; F. Schunter; P. Wernet 📂 Article 📅 1978 🏛 Springer 🌐 English ⚖ 315 KB

This study confirms close linkage for the GLO--Bf--HLA-B,C,A complex, and proves linkage between the MHC loci and PGM3. For GLO--PGM3 and Bf--PGM3, respectively, loose linkage seems to be likely, and close linkage can be excluded. Our mapping data on chromosome 6 favor the hypothesis that the PGM3 l

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Haplotype analysis of the linkage group HLA-A: HLA-B: Bf in Japanese
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Three hundred four HLA-A : HLA-B : Bf haplotypes of the Japanese population as deduced by family analysis are described. Several linkage disequilibriums were observed in the following two-factor haplotypes: HLA-A and HLA-B, HLA-A and Bf, and HLA-B and Bf. Positive linkage disequilibriums between HLA

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✍ K. Bender; A. Mayerová; R. Frank; C. Hiller; T. Wienker 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 275 KB

The analysis of 650 HLA-A:HAL-B:Bf three-factor haplotypes revealed significant associations only between alleles of the very closely linked genes HLA-A and HLA-B, and Bf, respectively. Most striking is the highly significnat association of the rare Bf variant F1 with HLA-B18 and of S1 with HLA-B13,