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Haplotype analysis of the linkage group HLA-A: HLA-B: Bf in Japanese

✍ Scribed by Satoshi Horai; Takeo Juji; Hachiro Nakajima

Publisher
Springer
Year
1979
Tongue
English
Weight
405 KB
Volume
51
Category
Article
ISSN
0340-6717

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✦ Synopsis

Three hundred four HLA-A : HLA-B : Bf haplotypes of the Japanese population as deduced by family analysis are described. Several linkage disequilibriums were observed in the following two-factor haplotypes: HLA-A and HLA-B, HLA-A and Bf, and HLA-B and Bf. Positive linkage disequilibriums between HLA-A and HLA-B noted in the present study seem to be Japanese specific when compared with the results obtained from other ethnic groups reported so far. The striking finding is that three HLA-B : Bf haplotypes, namely B12-BfF, B15-BfF, and B7-BfS, are common and show linkage disequilibrium in both Japanese and European Caucasians (German). This finding not only confirms the proximity of the HLA-B and Bf loci but also suggests that the interaction of the two genes plays an important role in the maintenance of stable linkage disequilibrium.

πŸ“œ SIMILAR VOLUMES

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## Abstract ## Background We previously reported the associations of human leukocyte antigen (HLA) (__DRB1__ and __DQB1__), __INS, CTLA4, IL2RA, ERBB3__ and __CLEC16A__ with Japanese type 1 diabetes (T1D). In this study, we jointly analysed these loci in addition to __IFIH1__ and __IL7R__. ## Met