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Mapping of the linkage group GLO-Bf-HLA-B,C,A-PGM3

✍ Scribed by J. Kömpf; S. Bissbort; F. Göhler; F. Schunter; P. Wernet

Publisher
Springer
Year
1978
Tongue
English
Weight
315 KB
Volume
44
Category
Article
ISSN
0340-6717

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✦ Synopsis

This study confirms close linkage for the GLO--Bf--HLA-B,C,A complex, and proves linkage between the MHC loci and PGM3. For GLO--PGM3 and Bf--PGM3, respectively, loose linkage seems to be likely, and close linkage can be excluded. Our mapping data on chromosome 6 favor the hypothesis that the PGM3 locus is situated on the HLA-A side of the MHC complex. Yet fine-structure mapping should be confirmed only by segregation analyses in crossover families by testing simultaneously all of the relevant marker loci within uniform family material.

📜 SIMILAR VOLUMES

Mapping of the linkage group GLO-Bf-HLA-
Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM3
✍ F. Schunter; P. Wernet; J. Kömpf; S. Bissbort; F. Göhler 📂 Article 📅 1978 🏛 Springer 🌐 English ⚖ 525 KB

Segregation analysis of informative families for chromosome 6 markers confirmed the map order GLO--Bf--HLA-(B, C)--HLA-A, and, surprisingly, implies that PGM3 is more probably located on the HLA-A than on the HLA-B side of the linkage group. Therefore the map position of PGM3 should be reconsidered,

Haplotype analysis of the linkage group
Haplotype analysis of the linkage group HLA-A: HLA-B: Bf in Japanese
✍ Satoshi Horai; Takeo Juji; Hachiro Nakajima 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 405 KB

Three hundred four HLA-A : HLA-B : Bf haplotypes of the Japanese population as deduced by family analysis are described. Several linkage disequilibriums were observed in the following two-factor haplotypes: HLA-A and HLA-B, HLA-A and Bf, and HLA-B and Bf. Positive linkage disequilibriums between HLA

Haplotype analysis of the linkage group
Haplotype analysis of the linkage group HLA-A:HLA-B:Bf and its bearing on the interpretation of the linkage disequilibrium
✍ K. Bender; A. Mayerová; R. Frank; C. Hiller; T. Wienker 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 275 KB

The analysis of 650 HLA-A:HAL-B:Bf three-factor haplotypes revealed significant associations only between alleles of the very closely linked genes HLA-A and HLA-B, and Bf, respectively. Most striking is the highly significnat association of the rare Bf variant F1 with HLA-B18 and of S1 with HLA-B13,