Concise Route to (–)- and (+)-Aphanorphine
✍ Scribed by Mohamed Medjahdi; José C. González-Gómez; Francisco Foubelo; Miguel Yus
- Book ID
- 102175234
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 321 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-193X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Successful oxidation of a key thiazoline intermediate allows an efficient synthesis of tiazofurin in four steps from commercially available 1%-acetoxy-2%,3%,5%-tri-O-benzoyl-b-D-ribofuranose.
An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)-2-azido-3methylbutanoic acid followed by reduction (Scheme 2).
Using the kinetically controlled Pictet-Spengler reaction, we have developed a three-step, diastereoselective and enantiospecific synthesis of the natural product demethoxy-fumitremorgin C in 21% overall yield.