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A Concise Route to Valacyclovir Hydrochloride

✍ Scribed by Prasada Raju V. N. K. V. Vetukuri; Ravindra Vedantham; Vijayavitthal Thippannachar Mathad; Pratap Reddy Padi; Vijaya Anand Ramasamy

Book ID
102257507
Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
136 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis

An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)-2-azido-3methylbutanoic acid followed by reduction (Scheme 2).

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