𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A concise, efficient route to fumitremorgins

✍ Scribed by Patrick D Bailey; Philip J Cochrane; Katrin Lorenz; Ian D Collier; David P.J Pearson; Georgina M Rosair

Book ID
104211443
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
70 KB
Volume
42
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Using the kinetically controlled Pictet-Spengler reaction, we have developed a three-step, diastereoselective and enantiospecific synthesis of the natural product demethoxy-fumitremorgin C in 21% overall yield.

πŸ“œ SIMILAR VOLUMES

A concise route to tiazofurin
A concise route to tiazofurin
✍ Richard S. Brown; James Dowden; Christelle Moreau; Barry V.L. Potter πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 73 KB

Successful oxidation of a key thiazoline intermediate allows an efficient synthesis of tiazofurin in four steps from commercially available 1%-acetoxy-2%,3%,5%-tri-O-benzoyl-b-D-ribofuranose.

A Concise Route to (+)-Lactacystin (I).
A Concise Route to (+)-Lactacystin (I).
✍ Hidenori Ooi; Norihisa Ishibashi; Yoshiharu Iwabuchi; Jun Ishihara; Susumi Hatak πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons βš– 10 KB
A Concise Route to Valacyclovir Hydrochl
A Concise Route to Valacyclovir Hydrochloride
✍ Prasada Raju V. N. K. V. Vetukuri; Ravindra Vedantham; Vijayavitthal Thippannach πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 German βš– 136 KB

An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)-2-azido-3methylbutanoic acid followed by reduction (Scheme 2).

Concise Route to (–)- and (+)-Aphanorphi
Concise Route to (–)- and (+)-Aphanorphine
✍ Mohamed Medjahdi; JosΓ© C. GonzΓ‘lez-GΓ³mez; Francisco Foubelo; Miguel Yus πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 321 KB
ChemInform Abstract: A Concise Route to
ChemInform Abstract: A Concise Route to Carbasugars.
✍ Yves Le Merrer; Christine Gravier-Pelletier; William Maton; Mehdi Numa; Jean-Cla πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 2 views