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Complexation Hydrogels for the Oral Delivery of Growth Hormone and Salmon Calcitonin

✍ Scribed by Carr, Daniel A.; Gómez-Burgaz, Marta; Boudes, Mathilde C.; Peppas, Nicholas A.

Book ID
126087654
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
746 KB
Volume
49
Category
Article
ISSN
0888-5885

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Biodegradable nanoparticles containing salmon calcitonin (sCT) were formulated using protein-fatty acid complexes, and their in vitro transport against a Caco-2 cell monolayer and the extent of in vivo oral uptake were assessed. Positively charged sCT was hydrophobically ion paired to form physical