Biodegradable nanoparticles containing salmon calcitonin (sCT) were formulated using protein-fatty acid complexes, and their in vitro transport against a Caco-2 cell monolayer and the extent of in vivo oral uptake were assessed. Positively charged sCT was hydrophobically ion paired to form physical
✦ LIBER ✦
Preparation and characterization of salmon calcitonin–sodium triphosphate ionic complex for oral delivery
✍ Scribed by Hea Eun Lee; Min Jung Lee; Cho Rong Park; A. Young Kim; Kyung Hwa Chun; Hee Jin Hwang; Dong Ho Oh; Sang Ok Jeon; Jae Seon Kang; Tae Sung Jung; Guang Jin Choi; Sangkil Lee
- Book ID
- 113693238
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 996 KB
- Volume
- 143
- Category
- Article
- ISSN
- 0168-3659
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The current work compared protective effects of various ovomucoid species against salmon calcitonin (sCT) metabolism by serine proteases. sCT solutions (50 mM) were incubated at 378C with trypsin (0.5 mM), a-chymotrypsin (0.1 mM), or elastase (0.48 mM) in 50 mM Tris buffer (pH 8.0) containing or lac